TREATMENT-RESISTANT DEPRESSION One in ten of the population are suffering from clinical depression at any one timeand one in five of all of us will get depression at some time in our lives. But up to one in three sufferers don’t respond to treatment and even those that do frequently relapse back into depression after just a short time. For these people, Treatment – Resistant Depression is an enduring and debilitating disease. Ruth Lang who works for the charity, Depression Alliance and suffers from this illness talks about her experiences. Dr Raj Persaud discusses the issues with Professor Phil Richardson at the Tavistock Clinic in London, and Glyn Lewis, Professor of Psychiatric Epidemiology at the University of Bristol. HAPPINESS and POSITIVE PSYCHOLOGY Among medical and psychological researchers happiness has always seemed a relatively trivial emotion to devote your career to when more pressing matters like schizophrenia or depression remain unsolved. But could it be that if we knew the secret of happiness then most mental health problems and negative emotions would automatically be solved? Dr Raj Persaud talks to psychologist, Dr Martin Seligman about his new book called Authentic Happiness which teaches us that happiness can be cultivated by identifying and using many of the strengths and traits that we already possess, our 'signature strengths' – kindness, originality, humour, optimism and generosity.